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- 02.09.2010 Sibutramine Increases Risk for MI and Stroke Among Patients with Heart Disease
The weight-loss drug sibutramine (Meridia) — up for review by FDA advisers on Sept. 15 — poses increased risk for cardiovascular events among adults with cardiovascular disease (CVD), according to a New England Journal of Medicine study.
Industry-supported researchers randomized nearly 10,000 overweight or obese adults with cardiovascular disease and/or diabetes to receive sibutramine or placebo. During 3.4 years' treatment, sibutramine recipients were at greater risk for nonfatal MI (4.1% vs. 3.2%) and stroke (2.6% vs. 1.9%), although not cardiovascular mortality. In subgroup analyses, the increased risks were seen among subjects with CVD and CVD plus diabetes, but not among those with diabetes alone. + zobacz więcej - 02.09.2010 FDA Issues Reminder on Increased Mortality Risk with Tigecycline
The FDA reminded physicians on Wednesday that the intravenous antibiotic tigecycline (Tygacil) is associated with an increased risk for death, relative to other antibiotics.
In a pooled analysis of 13 trials, 4% of patients given tigecycline subsequently died, compared with 3% of those given comparator antibiotics. The FDA is not certain about the cause of the mortality increase, but it speculates that it's related to infection progression. + zobacz więcej - 01.09.2010 Both Postterm and Preterm Birth Associated with Cerebral Palsy
Delivery at 42 weeks' gestation or more, as well as at 38 weeks or less, is associated with cerebral palsy (CP) among infants, according to a JAMA study.
Researchers analyzed Norwegian birth registry and insurance data on 1.7 million births to estimate the prevalence of CP according to gestational age. They found a U-shaped pattern, with higher rates of CP at the lowest and highest gestational ages. Compared with 40 weeks' gestation, the relative risk for CP at 37 weeks was 1.9, and for 42 weeks, it was 1.4. Adjustment for confounding factors did not significantly alter the results. + zobacz więcej - 01.09.2010 Benefits of Risk-Reducing Surgeries in BRCA Carriers Estimated
Women with BRCA mutations who undergo prophylactic mastectomy or salpingo-oophorectomy reduce their risks for breast and ovarian cancer, according to an observational study in JAMA.
Researchers studied some 2500 women with BRCA1 or BRCA2 mutations. About half of the patients underwent risk-reducing surgery. + zobacz więcej - 31.08.2010 Racial Differences in Stent Complications Not Attributable to Socioeconomic Factors
Black recipients of drug-eluting stents remain at increased risk for stent thrombosis regardless of comorbid conditions or socioeconomic factors, according to a Circulation study.
Researchers retrospectively compared post-stent outcomes in 1600 black patients and 5600 nonblack patients. After adjustment for socioeconomic status and comorbidities, black race remained a strong independent predictor of stent thrombosis. + zobacz więcej - 30.08.2010 Stalevo May Pose Increased Cardiovascular Risk
Patients taking Stalevo (carbidopa/levodopa plus entacapone) for Parkinson disease might be at greater risk for cardiovascular events than those taking Sinemet (carbidopa/levodopa), according to the FDA.
The agency conducted a meta-analysis after the STRIDE-PD trial found a higher rate of myocardial infarction in patients using Stalevo. The meta-analysis of 15 clinical trials found an association between Stalevo and cardiovascular events (relative risk, 2.46), but the results were no longer significant after excluding the STRIDE-PD data. + zobacz więcej - 30.08.2010 Many Patients with Chronic Fatigue Syndrome Carry a Viral Signature
Patients may be asking about a widely reported study linking mouse retroviruses with chronic fatigue syndrome (CFS). The paper appears in the Proceedings of the National Academy of Sciences.
Researchers found gene sequences from murine leukemia virus-related viruses in 32 of 37 patients with CFS, but in only 3 of 44 normal controls. The authors say their findings do not establish a causative role for the viruses in CFS, but may simply reflect the susceptibility of CFS patients to such infections. + zobacz więcej - 30.08.2010 Migraine with Aura Linked to Modest Increase in Mortality Risk
Adults who suffer migraine with aura face a modestly increased risk for cardiovascular and all-cause mortality, according to a BMJ study.
Researchers in Iceland assessed headache symptoms in nearly 19,000 adults (mean age, 53) and then followed them for roughly 26 years. Compared with subjects without headache, those experiencing migraine with aura at least monthly had a 21% higher risk for all-cause mortality and a 27% higher risk for cardiovascular mortality. Migraine without aura and nonmigraine headache did not pose increased risk. + zobacz więcej - 30.08.2010 Herpetic Antivirals in Early Pregnancy Not Associated with Birth Defects
Three antiviral drugs used to treat herpetic infections — when taken in the first trimester of pregnancy — are not associated with an increased risk for major birth defects, according to a cohort-based investigation in Denmark.
The study, which appears in JAMA, found a similar incidence of major defects (roughly 2%) in both the unexposed (over 800,000) and exposed (1800) fetuses. The drugs were acyclovir, valacyclovir, and famciclovir. + zobacz więcej - 20.08.2010 High School Football Players Most at Risk for Heat Illnesses
Among high school athletes, football players are most at risk for heat-related illness, particularly during preseason conditioning, according to an MMWR report.
CDC researchers analyzed data on nine sports at 100 high schools participating in the National High School Sports-Related Injury Surveillance Study from 2005 to 2009. They found 118 heat illnesses that resulted in at least 1 lost day of athletic participation, corresponding to an estimated 9200 heat-related illnesses nationally each year. + zobacz więcej
